摘要：

Parkinson's disease (PD) is a common clinical nervous system disease, which seriously affectsthe health of middle-aged and elderly people. The current treatment for Parkinson's disease is only aimed atalleviating early symptoms. Curcumin (CUR) is a natural product, which has been widely used in anti-inflammation, anticancer, and other fields. However, the potential mechanism of CUR in treating PD is currentlyunclear. The corresponding genes of CUR were harvested from the TCMSP, SwissTargetPrediction, SuperPred,PharmMapper, and SEA. Meanwhile, genes associated with PD were adopted from OMIM, TTD, DrugBank,MalaCards, and GeneCards databases. Through Gene Ontology (GO) and Kyoto Encyclopaedia of Genes andGenomes (KEGG) pathway enrichment analyses, therapeutic targeting KEGG pathways and functions were furthercollected. Then, STRING was used to generate the protein-protein interaction (PPI) network. The "drug-targetsdisease" network was built by Cystoscope. Finally, the binding between CUR and core targets of PD wasidentified via molecular docking technology. The network pharmacology analysis revealed 65 potential targetsrelated to the treatment of PD with CUR. The 10 core targets are CYP3A4, GSK3B, CYP19A1, CHEK1,COMT, CYP2A6, CYP2C19, HSD17B1, NFE2L2, and AHR. Moreover, KEGG enrichment analysis foundthat it was closely related to metabolic pathways, glycosaminoglycan degradation, steroid hormone biosynthesis,etc. The molecular docking results revealed that CUR had a strong binding ability with the PD target protein.In vitro experiments have shown that CUR can significantly improve oxidative damage caused by rotenoneintervention in PD SH-SY5Y cells and upregulate the level of key antioxidant pathway proteins Nrf2 and AHR.In a word, CUR may have therapeutic effects on PD through multitarget and multi-pathway, which providea scientific basis for further elaborating the mechanism of CUR in the treatment of PD.